rs1006737, CACNA1C

N. diseases: 27
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Major Depressive Disorder
CUI: C1269683
Disease: Major Depressive Disorder
0.900 GeneticVariation GWASDB Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. 20351715 2011
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.900 GeneticVariation GWASDB Genome-wide association analysis identifies 13 new risk loci for schizophrenia. 23974872 2013
Bipolar Disorder
CUI: C0005586
Disease: Bipolar Disorder
0.900 GeneticVariation GWASDB Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case-control sample. 23070075 2013
Bipolar Disorder
CUI: C0005586
Disease: Bipolar Disorder
0.900 GeneticVariation GWASDB Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. 18711365 2008
Attention deficit hyperactivity disorder
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
0.800 GeneticVariation GWASDB Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. 23453885 2013
Mental disorders
CUI: C0004936
Disease: Mental disorders
0.750 GeneticVariation GWASDB Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. 24280982 2014
Psychotic Disorders
CUI: C0033975
Disease: Psychotic Disorders
0.730 GeneticVariation GWASDB Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. 24280982 2014
Bipolar Disorder
CUI: C0005586
Disease: Bipolar Disorder
0.900 GeneticVariation GWASCAT Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. 24280982 2014
Bipolar Disorder
CUI: C0005586
Disease: Bipolar Disorder
0.900 GeneticVariation GWASCAT Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. 23453885 2013
Bipolar Disorder
CUI: C0005586
Disease: Bipolar Disorder
0.900 GeneticVariation GWASCAT Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. 20351715 2011
Major Depressive Disorder
CUI: C1269683
Disease: Major Depressive Disorder
0.900 GeneticVariation GWASCAT Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. 23453885 2013
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.900 GeneticVariation GWASCAT Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. 24280982 2014
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.900 GeneticVariation GWASCAT Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. 23453885 2013
Bipolar Disorder
CUI: C0005586
Disease: Bipolar Disorder
0.900 GeneticVariation GWASCAT Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. 18711365 2008
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.900 GeneticVariation GWASCAT Genome-wide association analysis identifies 13 new risk loci for schizophrenia. 23974872 2013
Major Depressive Disorder
CUI: C1269683
Disease: Major Depressive Disorder
0.900 GeneticVariation GWASCAT Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. 20351715 2011
Attention deficit hyperactivity disorder
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
0.800 GeneticVariation GWASCAT Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. 23453885 2013
Child Development Disorders, Pervasive
CUI: C0008074
Disease: Child Development Disorders, Pervasive
0.700 GeneticVariation GWASCAT Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. 23453885 2013
Major Depressive Disorder
CUI: C1269683
Disease: Major Depressive Disorder
0.900 GeneticVariation BEFREE We found that rs1006737 was associated with both schizophrenia (P(allele) = 0.0014, P(genotype) = 0.006, odds ratio (OR) = 1.384, 95% CI 1.134-1.690) and major depressive disorder (P(allele) = 0.0007, P(genotype) = 0.003, OR = 1.425, 95% CI 1.160-1.752). 24262814 2014
Bipolar Disorder
CUI: C0005586
Disease: Bipolar Disorder
0.900 GeneticVariation BEFREE This is most interesting because the common single-nucleotide polymorphism (SNP) most highly associated with BD is rs1006737, which we show here is a cis-expression quantitative trait locus for CACNA1C in human cerebellum, and the risk allele (A) is associated with decreased expression. 23979604 2014
Bipolar Disorder
CUI: C0005586
Disease: Bipolar Disorder
0.900 GeneticVariation BEFREE Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be overrepresented in patients suffering from bipolar disorder, schizophrenia or major depression. 19781653 2010
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.900 GeneticVariation BEFREE CACNA1C risk variant rs1006737 affects cortical white matter integrity in schizophrenia. 25470093 2014
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.900 GeneticVariation BEFREE These results add to the literature suggesting that rs1006737 may be associated with schizophrenia through its detrimental effect on endophenotypic traits. 22957138 2012
Bipolar Disorder
CUI: C0005586
Disease: Bipolar Disorder
0.900 GeneticVariation BEFREE On the other hand, our results indicate that alterations in the functional coupling between the prefrontal cortex and the medial temporal lobe could represent a neural system phenotype that is mediated by CACNA1C rs1006737 and other genetic susceptibility loci for schizophrenia and bipolar disorder. 23404764 2014
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.900 GeneticVariation BEFREE Our results further confirmed that rs1006737 should be categorized as an authentic risk SNP for schizophrenia in the general populations. 25588813 2015